Doctors login C4C Login

Rapid, safe and simple production of PRP

The Arthrex ACP® Double Syringe enables closed, rapid, and simple production of PRP. No synthetic separation gels are used as the PRP is separated from the other blood components in a purely physical process. This system, which has been used successfully for many years, enables the production of approx. 5–6 ml of PRP with a platelet concentration that is about two and a half times increased over baseline, coupled with simultaneous separation of leukocytes and erythrocytes. 1-3

Personalized Cell Therapy is a PRP (platelet rich plasma) procedure which harnesses the body’s own healing and regeneration processes. PRP’s medicinal effect originates from a multitude of growth factors and signaling molecules found in platelets and blood plasma. 4

The innovative PRP system from Arthrex allows simple preparation of clinically evaluated and proven PRP without having to compromise on safety and quality. 

The clinical efficiency of this composition of ACP (autologous conditioned plasma)  has been demonstrated in an FDA-approved level 1 study, among others. 5  In addition, the literature describes how the secretion of autologous hyaluronic acid is stimulated effectively by a platelet concentration in this range. 6

Speed and simplicity

  1. 15ml of blood are drawn directly into the Arthrex ACP® Double Syringe. 
  2. Mild centrifugation for 5 minutes. 
  3. The ACP is drawn into the internal syringe.
  4. The ACP can be injected directly from the syringe. If the ACP is injected within 30 minutes of being prepared, anticoagulant is not required. 

Possible applications

PRP has been clinically validated and established as a treatment concept in a wide variety of medical disciplines for a long time. 7-12

PRP particularly appeals to patients looking for a natural treatment result without the use of foreign substances such as botulinum toxin or hyaluronic acid. 

PRP injections are met with a high degree of patient satisfaction and, thanks to the closed Arthrex ACP® Double Syringe, which in the case of PRP does not come into contact with a separation gel or anticoagulants, are also a well-tolerated procedure.13-15

PRP in Aesthetic medicine, dermatology, plastic surgery

A. Skin rejuvenation: significant improvement in skin elasticity and turgor due to activation of collagen and hyaluronic acid synthesis. 16
B. Supportive treatment following ablative laser treatment: accelerated healing and greater patient satisfaction. 17, 18-25
C. Androgenic alopecia and alopecia areata: PRP injected into the scalp is a treatment option for hair loss. PRP stimulates the proliferation and differentiation of stem cells in hair follicles. 26, 27 
D. Wrinkles, contours, augmentation: significant improvement in superficial wrinkles with virtually no downtime. 28, 29

distributed by:
Croma-Pharma GmbH
Industriezeile 6, 2100 Leobendorf, Austria

Arthrex ACP® Double Syringe produced by:
Arthrex, Inc.
1370 Creekside Blvd
Naples, FL 34108, USA
www.arthrex.com

European Representative: 
Arthrex GmbH 
Erwin-Hielscher-Straße 9 81249 Munich, Germany

CE0086

References

1  Sundman EA, Cole BJ, Fortier LA. Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma. Am J Sports Med. 2011;39(10):2135-40 

2  Kisiday JD et al. Effects of Platelet-Rich Plasma Composition on Anabolic and Catabolic Activities in Equine Cartilage and Meniscal Explants. Cartilage. 2012;3:245-5
3 
Mazzocca AD et al. Platelet-rich plasma differs according to preparation method and human variability. Journal of Bone & Joint Surgery. 2012;94(4):308-16 

4 Steed DL. The role of growth factors in wound healing. Surg Clin North Am 1997;77(3):575-86 

5  Smith PA. Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis: An FDA-Sanctioned, Randomized, Double-blind, Placebo-controlled Clinical Trial. Am J Sports Med. 2016 Apr;44(4):884-91. doi: 10.1177/0363546515624678. Epub 2016 Feb 1. 

6  Anitua E et al. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009 Apr;42(2):162-70. doi: 10.1111/j.1365-2184.2009.00583.x. Epub 2009 Feb 24. 

7  Picard F et al. The growing evidence for the use of platelet-rich plasma on diabetic chronic wounds: A review and a proposal for a new standard care. Wound Repair Regen. 2015 Sep;23(5):638-43. doi: 10.1111/ wrr.12317. Epub 2015 Aug 25. 

8  A Hamid MS et al. Platelet-rich plasma injections for the treatment of hamstring injuries: a randomized controlled trial. Am J Sports Med. 2014 Oct;42(10):2410-8. doi: 10.1177/0363546514541540. Epub 2014 Jul 29. 

9  Murray DJ et al. Platelet-Rich-Plasma Injections in Treating Lateral Epicondylosis: a Review of the Recent Evidence. J Hand Microsurg. 2015 Dec;7(2):320-5. doi: 10.1007/s12593-015-0193-3. Epub 2015 Jul 8. 

10 Jeong DU et al. Clinical applications of platelet-rich plasma in patellar tendinopathy. Biomed Res Int. 2014;2014:249498. doi: 10.1155/2014/249498. Epub 2014 Jul 21. 

11 Kanchanatawan W et al. Short-term outcomes of platelet-rich plasma
injection for treatment of osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 2016 May;24(5):1665-77. doi: 10.1007/s00167-015-
3784-4. Epub 2015 Sep 19. 45
12  Leo MS et al. Systematic review of the use of platelet-rich plasma in aesthetic dermatology. J Cosmet Dermatol. 2015 Dec;14(4):315-23. doi: 10.1111/jocd.12167. Epub 2015 Jul 23. 

13  Ruemmelein B. Fraktionierte Laserbehandlungen und plättchenreiches Plasma. SZD. 5/2016 

14  Aust M, Jamchi S, Busch K. Platelet-Rich Plasma – Eine minimal-invasive Methode zur Behandlung alternder Haut am Unterlid. Face. 01/2016

15  Wied-Baumgartner S. Der Einsatz von ACP/PRP in der Mesoästhetik. 
Face. 01/2016

16 Anitua E et al. Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients. Rheumatology (Oxford) 2007;46(12):1769-72
17 NaJI et al. Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. DermatolSurg. 2011 Apr;37(4):463-8
18 Suh DH et al. Treatment of striaedistensaecombined enhanced penetration platelet-rich plasma and ultrasound after plasma fractional radiofrequency. J CosmetLaser Ther. 2012 Dec;14(6):272-6. doi: 10.3109/14764172.2012.738916
19 PetrovA. Efficiency of Carbon Dioxide Fractional Laser in Skin Resurfacing. Open AccessMacedJ Med Sci. 2016 Jun 15;4(2):271-6
20 Hui Q et al. The Clinical Efficacy of Autologous Platelet-Rich Plasma Combined with Ultra-Pulsed Fractional CO2 Laser Therapy for Facial Rejuvenation. RejuvenationRes. 2017;20(1):25-31. doi:10.1089/ rej.2016.1823.
21 Kim H, Gallo J. Evaluation of the effect of platelet-rich plasma on recovery after ablative fractional photothermolysis. JAMA Facial PlastSurg. 2015 Mar-Apr;17(2):97-102
22 Nita AC et al. Fat graft, laser CO2 and platelet-rich-plasma synergy in scars treatment. J Med Life. 2013;6(4):430-3
23 Nita AC et al. The synergy between lasers and adipose tissues surgery in cervicofacialrejuvenation: histopathological aspects. Rom J Morphol Embryol. 2013;54(4):1039-43
24 GawdatHI et al. Autologous platelet rich plasma: topical versus intradermal after fractional ablative carbon dioxide laser treatment of atrophic acne scars. DermatolSurg. 2014 Feb;40(2):152-61
25 Lee et al. The efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: a simultaneous split-face trial. DermatolSurg. 2011 Jul;37(7):931-8
26 Li ZJ et al. Autologous platelet-rich plasma: A potential therapeutic tool for promoting hair growth. DermatolSurg2012 Jul;38(7 Pt 1):1040-6
27 Gupta AK, CarvielJ. A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia. DermatolSurg. 2016 Dec;42(12):1335–9
28 Wied-Baumgartner S. Plättchen-reiches Plasma (PRP/ACP): Eine natürliche Methode zu ästhetischen Handverjüngung. Ästhetische Dermatologie1/2017
29 Elnehrawy NY et al. Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles. J Cosmet Dermatol. 2017 Mar;16(1):103-11 doi: 10.1111/jocd.12258. Epub2016 Jul 29